Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I

2000 ◽  
Vol 30 (5) ◽  
pp. 1496-1506 ◽  
Author(s):  
Mario Lobigs ◽  
Gareth Chelvanayagam ◽  
Arno Müllbacher
Keyword(s):  
Endoplasmic Reticulum ◽  
Antigen Presentation ◽  
Proteolytic Processing ◽  
Class I ◽  
Major Histocompatibility ◽  
Major Histocompatibility Class ◽  
Major Histocompatibility Class I

scholarly journals Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection

2009 ◽  
Vol 182 (2) ◽  
pp. 902-911 ◽  
Author(s):  
Matthew D. H. Lay ◽  
Lei Zhang ◽  
Ruy M. Ribeiro ◽  
Scott N. Mueller ◽  
Gabrielle T. Belz ◽  
...  
Keyword(s):  
Antigen Presentation ◽  
Acute Infection ◽  
Class I ◽  
Major Histocompatibility ◽  
Major Histocompatibility Class ◽  
Kinetics Of ◽  
Major Histocompatibility Class I

scholarly journals Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

1989 ◽  
Vol 9 (2) ◽  
pp. 847-850 ◽  
Author(s):  
M E Lambert ◽  
Z A Ronai ◽  
I B Weinstein ◽  
J I Garrels
Keyword(s):  
Dna Damage ◽  
Protein Synthesis ◽  
Human Fibroblasts ◽  
Simian Virus 40 ◽  
Class I ◽  
Major Histocompatibility ◽  
Class I Mhc ◽  
Mhc I ◽  
Major Histocompatibility Class ◽  
Major Histocompatibility Class I

Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.

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